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MAB4162

Sigma-Aldrich

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17

clone MM4.17, Chemicon®, from mouse

Sinónimos:

P-glycoprotein, CD243, p170, Pgp

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

300

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MM4.17, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG2aκ

NCBI accession no.

NM_000927.3

UniProt accession no.

P08183

shipped in

wet ice

Categorías relacionadas

Specificity

Recognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Cianfriglia, 1994 and Poloni, 1995).

Application

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH.
Flow Cytometry

Immunohistochemistry on formalin fixed paraffin embedded sections

Confocal and Electron Microscopy

ELISA

Optimal working dilutions must be determined by end user.

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Marine Chartrain et al.
PloS one, 7(5), e36762-e36762 (2012-06-08)
Metastatic melanoma is the most aggressive skin cancer. Recently, phenotypically distinct subpopulations of tumor cells were identified. Among them, ABCB5-expressing cells were proposed to display an enhanced tumorigenicity with stem cell-like properties. In addition, ABCB5(+) cells are thought to participate
Paola Turella et al.
The Journal of biological chemistry, 281(33), 23725-23732 (2006-06-14)
The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. CEM-VBL10, CEM-VBL100, and U-2 OS/DX580. The mechanism of cell death triggered by NBDHEX has been deeply investigated in leukemia cell lines. Kinetic data indicate a
Jingwei Zhang et al.
British journal of pharmacology, 165(1), 120-134 (2011-05-28)
Intracellular pharmacokinetics of anticancer drugs in multi-drug resistance (MDR) cancer cells is hugely important in the evaluation and improvement of drug efficacy. By using adriamycin as a probe drug in MDR cancer cells, we developed a cellular pharmacokinetic-pharmacodynamic (PK-PD) model
Masahiro Yasunaga et al.
Scientific reports, 4, 4852-4852 (2014-05-02)
The treatment of colorectal cancer (CRC) might be improved by the identification of a signalling pathway that could be targeted with novel therapeutics. The results of this study indicate that the taurine transporter SLC6A6 is highly expressed in CRC cells
Wanyuan Chen et al.
Oncology reports, 41(1), 67-76 (2018-10-27)
Pancreatic cancer (PC) is a lethal solid malignancy with resistance to traditional chemotherapy. Recently, considerable studies have demonstrated the ubiquitous antitumor properties of gene therapy mediated by the oncolytic vaccinia virus. The second mitochondrial‑derived activator of caspase (Smac) has been

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