440025

Luteolin

An antioxidant flavonoid and a free radical scavenger.

• Sinónimos: Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
• Fórmula empírica (notación de Hill): C₁₅H₁₀O₆
• Número de CAS: 491-70-3
• Peso molecular: 286.24
• Número MDL: MFCD00017309
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• descripción: Merck USA index - 14, 5614
• Ensayo: ≥90% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: aqueous base: 1.4 mg/mL; DMSO: 7 mg/mL; ethanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [o]1c2c([c](cc1c3cc(c(cc3)O)O)=O)c(cc(c2)O)O
• InChI: 1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
• Clave InChI: IQPNAANSBPBGFQ-UHFFFAOYSA-N

Descripción

Descripción general

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
rat liver cytosolic glutathione S-transferase activity

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Otras notas

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable