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Merck
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Documentos clave

36-006

Sigma-Aldrich

Anti-phospho-CPI-17 (Thr38) Antibody

Upstate®, from rabbit

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

purified antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

rabbit, bovine, human, pig, mouse, rat

fabricante / nombre comercial

Upstate®

técnicas

activity assay: suitable

isotipo

IgG

Nº de acceso NCBI

NM_033256.1

Nº de acceso UniProt

Q96A00

Condiciones de envío

dry ice

modificación del objetivo postraduccional

phosphorylation (pThr38)

Información sobre el gen

bovine ... Ppp1R14A(615348)
human ... PPP1R14A(94274)
mouse ... Ppp1R14A(68458)
pig ... Ppp1R14A(397610)
rat ... Ppp1R14A(114004)

Especificidad

CPI-17 phosphorylated on Threonine 38.

Inmunógeno

Peptide corresponding to amino acids 35-46 of human CPI-17.

Aplicación

Detect phospho-CPI-17 (Thr38) using this Anti-phospho-CPI-17 (Thr38) Antibody validated for use in EA.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Calidad

Routinely evaluated by immunoblot on phosphorylated recombinant CPI-17.

Descripción de destino

~17 kDa

Forma física

0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%.
Format: Purified
Protein A purified

Almacenamiento y estabilidad

2 years at -20°C

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ketrija Touw et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G66-G76 (2011-10-08)
Seventy-six percent of diabetic patients develop gastrointestinal symptoms, such as constipation. However, the direct effects of diabetes on intestinal smooth muscle are poorly described. This study aimed to identify the role played by smooth muscle in mediating diabetes-induced colonic dysmotility.
Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.
Mahavadi, S; Bhattacharya, S; Kumar, DP; Clay, C; Ross, G; Akbarali, HI; Grider, JR; Murthy, KS
American Journal of Physiology: Gastrointestinal and Liver Physiology null
T Kitazawa et al.
The Journal of biological chemistry, 275(14), 9897-9900 (2000-04-01)
Myosin light chain phosphatase (MLCP) plays a pivotal role in smooth muscle contraction by regulating Ca(2+) sensitivity of myosin light chain phosphorylation. A smooth muscle phosphoprotein called CPI-17 specifically and potently inhibits MLCP in vitro and in situ and is
Ayça Toprak Semiz et al.
Life sciences, 255, 117834-117834 (2020-05-27)
Hydrogen sulfide (H2S) is shown in ocular tissues and suggested to involve in the regulation of retinal circulation. However, the mechanism of H2S-induced relaxation on retinal artery is not clarified yet. Herein, we aimed to evaluate the role of several
Karen A Fagan et al.
American journal of physiology. Lung cellular and molecular physiology, 287(4), L656-L664 (2004-02-24)
RhoA GTPase mediates a variety of cellular responses, including activation of the contractile apparatus, growth, and gene expression. Acute hypoxia activates RhoA and, in turn, its downstream effector, Rho-kinase, and previous studies in rats have suggested a role for Rho/Rho-kinase
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