231085

Cilostamide

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).

• Sinónimos: Cilostamide, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide, OPC 3689
• Fórmula empírica (notación de Hill): C₂₀H₂₆N₂O₃
• Número de CAS: 68550-75-4
• Peso molecular: 342.43
• MDL number: MFCD00673958
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N

Descripción

General description

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE 3

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 70 nM against PDE III

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable