182690

AhR Agonist V, VAF347

The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Sinónimos: AhR Agonist V, VAF347, (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
• Fórmula empírica (notación de Hill): C₁₇H₁₁ClF₃N₃
• Número de CAS: 574759-62-9
• Peso molecular: 349.74
• UNSPSC Code: 12352200
• PubChem Substance ID: 10172275
• NACRES: NA.51

Propiedades

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: C1=CC(=CC(=C1)Cl)C2=NC(=NC=C2)NC3=CC=C(C=C3)C(F)(F)F

Descripción

General description

A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC₅₀ of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Platzer, B., et al. 2009. J. Immunol.183, 66.
Hauben, E., et al. 2008. Blood118, 1214.
Lawrence, B.P., et al. 2008. Blood112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable