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Merck
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Key Documents

05-857

Sigma-Aldrich

Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal

clone 2N8, Upstate®, from rabbit

Sinónimos:

KAT13A

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2N8, monoclonal

species reactivity

vertebrates, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_005417

UniProt accession no.

P12931

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr416)

Gene Information

human ... SRC(6714)

Specificity

phospho-c-Src (Tyr416)

Immunogen

synthetic peptide containing the sequence ...NE[pY]TA, where pY corresponds to phosphotyrosine at position 416 of c-Src.

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling
This Anti-phospho-Src family (Tyr416) Antibody, clone 2N8 is validated for use in WB for the detection of phospho-Src family (Tyr416).

Quality

Routinely evaluated by immunoblot of endogenous phospho-c-Src immunoprecipitated from NIH/3T3 RIPA lysates with anti-Src, clone GD11 agarose beads (Cat # 16-186)

Target description

60kDa

Linkage

Replaces: 16-249

Physical form

Format: Purified
Protein A purified

Storage and Stability

2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Structure and regulation of Src family kinases.
Boggon, Titus J and Eck, Michael J
Oncogene, 23, 7918-7927 (2004)
The interplay between Src family kinases and receptor tyrosine kinases.
Bromann, Paul A, et al.
Oncogene, 23, 7957-7968 (2004)
Molecular interdiction of Src-family kinase signaling in hematopoietic cells.
Geahlen, Robert L, et al.
Oncogene, 23, 8024-8032 (2004)
Suowen Xu et al.
Cellular signalling, 28(3), 117-124 (2015-12-27)
Endothelial dysfunction, characterized by impaired activation of endothelial nitric oxide (NO) synthase (eNOS) and ensued decrease of NO production, is a common mechanism of various cardiovascular pathologies, including hypertension and atherosclerosis. Laminar blood flow-mediated specific signaling cascades modulate vascular endothelial
Src protein-tyrosine kinase structure and regulation.
Roskoski, Robert
Biochemical and biophysical research communications, 324, 1155-1164 (2004)
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