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Merck
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Key Documents

05-486

Sigma-Aldrich

Anti-FADD Antibody, clone 1F7

clone 1F7, Upstate®, from mouse

Sinónimos:

Anti-GIG3, Anti-IMD90, Anti-MORT1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

1F7, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

NM_003824

UniProt accession no.

Q13158

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... FADD(8772)
mouse ... Fadd(14082)

Specificity

FADD

Immunogen

GST-tagged full-length fusion protein corresponding to human FADD

Application

Anti-FADD Antibody, clone 1F7 detects level of FADD & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Quality

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

Target description

28kDa

Linkage

Replaces: 04-1113

Physical form

Format: Purified
PBS, pH 7.2 and 50% glycerol
Protein A chromatography

Storage and Stability

2 years at -20°C

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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International Journal of Physiology, Pathophysiology and Pharmacology null
Hayley I Muendlein et al.
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Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11-mediated gasdermin D pore formation. In vivo, responses to lipopolysaccharide (LPS) result in IL-1β secretion. In vitro, however, murine
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K Kim et al.
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Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling
McDonald, E. R., 3rd, et al
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Simon Thompson et al.
The Journal of biological chemistry, 286(22), 19331-19339 (2011-04-12)
We have previously shown that the cell death-promoting protein Bcl-2-interacting mediator of cell death (Bim) is ubiquitinated and degraded following a neuroprotection-conferring episode of brief ischemia (preconditioning). Here, we identify the E3 ligase that ubiquitinates Bim in this model, using
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