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Merck
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Key Documents

05-337

Sigma-Aldrich

Anti-MARCKS Antibody, clone 2F12

ascites fluid, clone 2F12, Upstate®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2F12, monoclonal

species reactivity

bovine, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_002356

UniProt accession no.

P29966

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MARCKS(4082)

Specificity

MARCKS

Immunogen

Purified recombinant human MARCKS; Epitope mapped to the carboxyl-terminal.

Application

Anti-MARCKS Antibody, clone 2F12 detects level of MARCKS & has been published & validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Quality

routinely evaluated by immunoblot on bovine brain extract

Target description

none given

Physical form

Ascites
mouse ascites containing 0.05% sodium azide

Storage and Stability

6 months at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Shijing Fang et al.
American journal of physiology. Lung cellular and molecular physiology, 304(8), L511-L518 (2013-02-05)
Myristoylated alanine-rich C kinase substrate (MARCKS) protein has been recognized as a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. We recently showed that two intracellular chaperones, heat shock protein 70 (HSP70) and
Jin-Ah Park et al.
The American journal of pathology, 171(6), 1822-1830 (2007-12-07)
Mucin hypersecretion is a major pathological feature of many respiratory diseases, yet cellular mechanisms regulating secretion of mucin have not been fully elucidated. Previously, we reported that mucin hypersecretion induced by human neutrophil elastase involves activation of protein kinase C
20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C
Lange, A., et al
The Journal of Biological Chemistry, 272, 27345-27352 (1997)

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