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Merck

860065P

Avanti

Ganglioside GM1 (Ovine Brain)

Avanti Research - A Croda Brand

Sinónimos:

110952

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About This Item

Número de CAS:
UNSPSC Code:
12352211
NACRES:
NA.25

description

GM1 Ganglioside (Brain, Ovine-Sodium Salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860065P-1mg)
pkg of 1 × 10 mg (860065P-10mg)
pkg of 1 × 25 mg (860065P-25mg)
pkg of 1 × 5 mg (860065P-5mg)

manufacturer/tradename

Avanti Research - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H

InChI

1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1

InChI key

CNLVNZJJSHZYAS-ALSOZVJRSA-N

Categorías relacionadas

General description

Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units.

Application

Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type−synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.

Biochem/physiol Actions

Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.

Packaging

5 mL Amber Glass Screw Cap Vial (860065P-10mg)
5 mL Amber Glass Screw Cap Vial (860065P-1mg)
5 mL Amber Glass Screw Cap Vial (860065P-25mg)
5 mL Amber Glass Screw Cap Vial (860065P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Quantitative Comparison of GM1 Gangliosidosis Afflicted Ovine Tissue using Thin-Layer Chromatography, Mass Spectrometry and Nuclear Magnetic Resonance
Mata CV and Mitchell JC
Faseb Journal, 33(1), 796-715 (2019)
Formation of supported lipid bilayers containing phase-segregated domains and their interaction with gold nanoparticles
Melby ES, et al.
Environmental science : water research & technology, 3(1), 45-55 (2016)
The multi-tasked life of GM1 ganglioside, a true factotum of nature
Ledeen RW and Wu G
Trends in Biochemical Sciences, 40(7), 407-418 (2015)
Tyuji Hoshino et al.
The journal of physical chemistry. B, 117(27), 8085-8094 (2013-05-22)
Accumulation and fibril formation of amyloid β (Aβ) peptides onto a ganglioside-rich lipid membrane is a cause of neuro-disturbance diseases. To find out a measure for suppressing the nucleation of a seed for amyloid fibrils, the mechanism of the initial
Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain
Zhang Y, et al.
Scientific reports, 6(, 25289-25289 (2016)

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