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Key Documents

SAB2702152

Sigma-Aldrich

Monoclonal Anti-COPS5 antibody produced in mouse

Synonym(s):

CSN5, JAB1, MOV-34, SGN5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2A10
monoclonal

form

liquid

mol wt

38 kDa

species reactivity

human, rat, mouse, Drosophila

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:500-1:3000

isotype

IgG2b

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COPS5(10987)

Immunogen

The full-length mouse JAB-1 gene expressed in E. coli.

Application

For IP: Use at a concentration of 0.5 - 1 μg/mL. For WB: Use at a dilution of 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher.

Biochem/physiol Actions

JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Phosphate-buffered saline, pH 7.4, containing no preservatives

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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