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N7787

Sigma-Aldrich

NS3694

≥98%, powder

Synonym(s):

4-Chloro-2-[3-(3-trifluoromethyl-phenyl)-ureido]benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C15H10ClF3N2O3
CAS Number:
426834-38-0
Molecular Weight:
358.70
MDL number:
MFCD00249000
UNSPSC Code:
12352200
PubChem Substance ID:
24724557
NACRES:
NA.77

Assay

≥98%

form

powder

solubility

DMSO: soluble 22 mg/mL
H2O: insoluble <5 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F

InChI

1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)

InChI key

GNCZTZCPXFDPLI-UHFFFAOYSA-N

Gene Information

human ... GRIK1(2897)

Application

NS3694 may be used as an apoptosis inhibitor to study the relationship between the cellular mechanisms controlled by amputation-induced myeloid lineage activity.

Biochem/physiol Actions

NS3694 can prevent the active apoptosome complex formation.
NS3694 is an Inhibitor of apoptosome formation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the formation of a caspase-activating protein complex called the apoptosome, whereas
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Development (Cambridge, England), 147(3) (2020-01-29)
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