M7317

Monoclonal Anti-MDR3 P-Glycoprotein antibody produced in mouse

250 μg/mL, clone P₃II-26, tissue culture supernatant

• Synonym(s): Anti-ABC21, Anti-GBD1, Anti-ICP3, Anti-MDR2, Anti-MDR2/3, Anti-MDR3, Anti-PFIC-3, Anti-PGY3
• MDL number: MFCD03791722
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: tissue culture supernatant
• antibody product type: primary antibodies
• clone: P₃II-26, monoclonal
• species reactivity: human
• concentration: 250 μg/mL
• technique(s): immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues); immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections; western blot: suitable
• isotype: IgG2b
• UniProt accession no.: P21439
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ABCB11(8647) , ABCB4(5244)

Description

General description

Multidrug resistance protein 3 (MDR3) is also known as ATP binding cassette subfamily B member 4. It is expressed in hepatocytes and made up of 1279 amino acids. The gene encoding it is localized on human chromosome 7q21.12 and consists of 27 exons.

Specificity

Reacts with an internal epitope of MDR3. Does not cross-react with human MDR1 P-gp.

Immunogen

MDR3 P-gp (amino acids 629-692) GST fusion protein.

Biochem/physiol Actions

Multidrug resistance protein 3 (MDR3) acts as an ATP-dependent exporter and transfers phospholipids, particularly phosphatidylcholine (PC), into bile. Dysfunctioning of MDR3 leads to excess of bile salts in primary bile and further leads to liver diseases.

Physical form

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable