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C4905

Sigma-Aldrich

Galactocerebrosides from bovine brain

≥97% (TLC)

Synonym(s):

Ceramide β-D-galactoside

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.77

Quality Level

Assay

≥97% (TLC)

form

powder

storage temp.

−20°C

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General description

A mixture of type I (containing α-hydroxy fatty acid) and type II (containing non-hydroxy fatty acid) cerebrosides. Galactocerebroside (GalCer) is a glycosphingolipid, that consists of a single galactose residue, connected to ceramide . GalCer is present within the exofacial leaflet of the lipid bilayer.

Application

Galactocerebrosides from bovine brain has been used to find the receptor activity of surface-immobilized galactosylceramide. It has also been used in sulfatide binding assay.

Biochem/physiol Actions

Galactocerebroside (GalCer) participates in the progression and maintenance of myelin. This oligodendroglial lipid is used as an immunohistochemical tool for studying oligodendrocytes.
Galactose linked to ceramide by a β-glycosidic linkage; the major lipid in adult brain, representing approximately 16% of total lipid; they are mainly localized to myelin and are markedly reduced in demyelinating diseases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Scaffold-forming and adhesive contributions of synthetic laminin-binding proteins to basement membrane assembly
McKee K K, et al.
The Journal of Biological Chemistry, 284(13), 8984-8994 (2009)
Oligodendrocyte morphology
Encyclopedia of Neuroscience (2009)
Piglet ileal mucus contains protein and glycolipid (galactosylceramide) receptors specific for Escherichia coli K88 fimbriae.
Blomberg L, et al.
Infection and Immunity, 61(6), 2526-2531 (1993)
Gangliosides and Autoimmune Peripheral Nerve Diseases
Progress in Molecular Biology and Translational Science, 156, 355-382 (2018)
F Persat et al.
Infection and immunity, 64(9), 3682-3687 (1996-09-01)
The effect on human peripheral blood mononuclear cells (PBMCs) of neutral glycosphingolipids extracted from metacestodes of the parasite Echinococcus multilocularis was investigated. Neutral glycosphingolipids inhibited [3H]thymidine uptake by human PBMCs upon stimulation by mitogens such as phytohemagglutinin A and pokeweed

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