A3085

5-(N-Ethyl-N-isopropyl)amiloride

≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor

• Synonym(s): EIPA
• Empirical Formula (Hill Notation): C₁₁H₁₈ClN₇O
• CAS Number: 1154-25-2
• Molecular Weight: 299.76
• MDL number: MFCD00151710
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278223
• NACRES: NA.77

Properties

• product name: 5-(N-Ethyl-N-isopropyl)amiloride,
• biological source: synthetic
• Quality Level: 200
• Assay: ≥98% (TLC)
• form: powder
• mp: 202-205 °C (lit.)
• solubility: methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
• storage temp.: 2-8°C
• SMILES string: CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
• InChI: 1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
• InChI key: QDERNBXNXJCIQK-UHFFFAOYSA-N
• Gene Information: human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , SLC9A5(6553) ; mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) ; rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a2(24783) , Slc9a3(24784) , Slc9a4(24785)

Description

Application

5-(N-Ethyl-N-isopropyl)amiloride has been used:

• as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
• in Pluronic F-127 stock solution for Drosophila larval live-imaging
• in choline chloride solution as an experimental perfusate, to study the effect of Na⁺/H⁺ inhibition on jejunal loop perfusion in vivo

Biochem/physiol Actions

Selective blocker of Na⁺/H⁺ antiport

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves