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270A-1

Sigma-Aldrich

IgM Rabbit Polyclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (270A-14)
vial of 0.5 mL concentrate (270A-15)
bottle of 1.0 mL predilute (270A-17)
vial of 1.0 mL concentrate (270A-16)
bottle of 7.0 mL predilute (270A-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

General description

Anti-IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes. This antibody is useful when identifying lymphomas, plasmacytomas, and B-cell lineage derived Hodgkin′s lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell lymphomas is possible with clonal gene rearrangement studies.

Quality


IVD
IVD
IVD
RUO

Linkage

IgM (polyclonal) Positive Control Slides, Product No. 270S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Masaru Kojima et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(12), 875-880 (2003-03-21)
Nodal marginal zone B-cell lymphomas (NMZBL) occasionally represent prominent plasma cell differentiation. Recently, we presented a patient with NMZBL who exhibited histological features that resembled plasmacytoma arising from a localized plasma cell variant of Castleman's disease. To further clarify the
C J de Boer et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 8 Suppl 2, 109-117 (1997-01-01)
Mantle-cell lymphoma comprises 2%-10% of all non-Hodgkin's lymphomas (NHLs). Patients present with generalized disease, and have a poor prognosis. Three different histologic patterns (mantle zone, nodular, and diffuse) and three different cytological variants (classical, blastic, and pleomorphic) have been described.
Manual of Diagnostic Antibodies for Immunohistology, 217-219 (1999)
Tissue section immunologic methods in lymphomas
Warnake, R., et al.
Diagnostic Immunohistochemistry (Masson Publishing), 203-221 (1981)
S E Pambuccian et al.
The American journal of surgical pathology, 21(2), 179-186 (1997-02-01)
Tumoral amyloidosis (amyloidoma) of bone is a rare condition characterized by the massive destructive deposition of AL amyloid in bones. We report three cases. The patients ranged in age from 45 to 78 years and had tumors located in the
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