Journal of pharmaceutical sciences, 94(5), 1004-1012 (2005-03-29)
Milling is a common procedure to improve bioavailability of many active pharmaceutical ingredients (APIs), which typically have low solubility in water. But such micronization can yield an increase in the cohesiveness of particles. Although particle cohesiveness is desirable for tablet
Six-week-old male F344 rats were given a mixture of 0.01% diethylnitrosamine, 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine and 0.02% N-methyl-N'-nitro-N-nitrosoguanidine in their drinking water for 1 week. When 0.8%, 0.4%, or 0% of a mixture of non-steroidal anti-inflammatory drugs (NSAIDs) (acetaminophen, aspirin, dipyrone plus
Chemical & pharmaceutical bulletin, 52(5), 524-529 (2004-05-11)
We prepared and characterized a grinding-induced equimolar complex of thiourea with ethenzamide. When thiourea and ethenzamide were co-ground at a molar ratio of 3 : 1, new powder X-ray diffraction (PXRD) peaks were observed in addition to PXRD peaks of
In this study, the rapid expansion of the supercritical solutions (RESS) process was used to produce microparticles of a commonly used anti-inflammatory drug, ethenzamide. The effects of process parameters in RESS including the extraction temperature, pre-expansion temperature, and post-expansion temperature
Journal of controlled release : official journal of the Controlled Release Society, 120(3), 205-210 (2007-06-22)
We studied the use of a 4-fluid nozzle spray drier as a new one-step method for preparing drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs. We employed ethenzamide (EZ) and flurbiprofen (FP) as poorly water-soluble drugs
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