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A8060

Sigma-Aldrich

Acrylic acid N-hydroxysuccinimide ester

≥90%, for peptide synthesis

Synonym(s):

N-Acryloxysuccinimide

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About This Item

Empirical Formula (Hill Notation):
C7H7NO4
CAS Number:
38862-24-7
Molecular Weight:
169.13
MDL number:
MFCD00078261
UNSPSC Code:
12352005
PubChem Substance ID:
57653888
NACRES:
NA.22

product name

Acrylic acid N-hydroxysuccinimide ester, ≥90%

Assay

≥90%

form

powder

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

C=CC(=O)ON1C(=O)CCC1=O

InChI

1S/C7H7NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2H,1,3-4H2

InChI key

YXMISKNUHHOXFT-UHFFFAOYSA-N

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Application

Acrylic acid N-hydroxysuccinimide ester (NAS) is a general acrylating agent that is used in the synthesis of:
  • Acrylated hyaluronic acid (HA) hydrogel for bone regeneration applications.
  • Injectable, biodegradable, and thermosensitive copolymers for tissue engineering.
  • Imidazole-based biocompatible, aqueous quantum dots (QDs).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protein-reactive, thermoresponsive copolymers with high flexibility and biodegradability.
Guan J, et al.
Biomacromolecules, 9(4), 1283-1292 (2008)
Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells.
Kim J, et al.
Biomaterials, 28(10), 1830-1837 (2007)
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
Liu W, et al.
Journal of the American Chemical Society, 132(2), 472-483 (2009)
Farshad Oveissi et al.
Biomaterials science, 7(3), 926-937 (2018-12-07)
Novel hydrogels with tunable mechanical properties similar to human soft tissue have increasing applications in biomedicine, soft robotics, and biocompatible electronics. However, most of these materials require multiple-step fabrication, are not robust, and compromise bioactivity. Thus, aiming to address these
Fred Y Shen et al.
Nature communications, 11(1), 4632-4632 (2020-09-17)
Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost
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