359181

Tetraethyl methylenediphosphonate

97%

• Synonym(s): Bis(diethoxyphosphinyl)methane, Methylenediphosphonic acid tetraethylester, NSC 133889
• Linear Formula: CH₂[P(O)(OCH₂CH₃)₂]₂
• CAS Number: 1660-94-2
• Molecular Weight: 288.21
• Beilstein: 1813241
• EC Number: 216-764-5
• MDL number: MFCD00039887
• UNSPSC Code: 12352108
• PubChem Substance ID: 24862057
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 97%
• form: liquid
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.442 (lit.)
• bp: 171-174 °C/11 mmHg (lit.)
• density: 1.16 g/mL at 25 °C (lit.)
• functional group: phosphonate
• SMILES string: CCOP(=O)(CP(=O)(OCC)OCC)OCC
• InChI: 1S/C9H22O6P2/c1-5-12-16(10,13-6-2)9-17(11,14-7-3)15-8-4/h5-9H2,1-4H3
• InChI key: STJWVOQLJPNAQL-UHFFFAOYSA-N

Description

Application

Reactant for synthesis of:

• Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
• Unnatural alpha-amino acid derivatives containing gem-biphosphonates
• Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
• Lycopene via Wittig-Horner reaction
• Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
• Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 230.0 °F - closed cup
• Flash Point(C): 110 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves