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About This Item
Empirical Formula (Hill Notation):
C8H6FN
CAS Number:
Molecular Weight:
135.14
Beilstein:
112192
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
98%
mp
72-76 °C (lit.)
functional group
fluoro
SMILES string
Fc1ccc2cc[nH]c2c1
InChI
1S/C8H6FN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H
InChI key
YYFFEPUCAKVRJX-UHFFFAOYSA-N
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General description
6-Fluoroindole is a halogen substituted indole. Experimental ionization potential of 6-fluoroindole has been evaluated. Preparation of 6-fluoroindole via nitration of indoline has been reported.
Application
6-Fluoroindole may be used as reactant in the preparation of:
- tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- antibacterial agents
- antifungal agents
- Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the management of hyperglycemia in diabetes
- potent selective serotonin reuptake inhibitors
- inhibitors of HIV-1 attachment
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Journal of Medicinal Chemistry, 36, 2242-2242 (1993)
Synthesis of 5-and 6-Halogenoindoles from Indoline
Ikan R, et al.
Israel J. Chem., 2(2), 37-42 (1964)
H Dalton King et al.
Journal of medicinal chemistry, 53(21), 7564-7572 (2010-10-19)
A series of conformationally restricted homotryptamines has been synthesized and shown to be potent inhibitors of hSERT. Conformational restriction of the homotryptamine side chain was attained by the insertion of a cyclopentyl ring, with the indole ring and the terminal
S Jimmy Budiardjo et al.
ACS synthetic biology, 5(12), 1475-1484 (2016-07-09)
Chemical biology has long sought to build protein switches for use in molecular diagnostics, imaging, and synthetic biology. The overarching challenge for any type of engineered protein switch is the ability to respond in a selective and predictable manner that
Na, Y. M.
Bull. Korean Chem. Soc., 31, 3467-3467 (2010)
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