15502

1-Boc-piperazine

≥98.0% (GC)

• Synonym(s): tert-Butyl piperazine-1-carboxylate
• Empirical Formula (Hill Notation): C₉H₁₈N₂O₂
• CAS Number: 57260-71-6
• Molecular Weight: 186.25
• Beilstein: 879985
• MDL number: MFCD00075265
• UNSPSC Code: 12352100
• eCl@ss: 32160406
• PubChem Substance ID: 57647377
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: ≥98.0% (GC)
• form: solid
• mp: 43-47 °C (lit.); 43-47 °C
• SMILES string: CC(C)(C)OC(=O)N1CCNCC1
• InChI: 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3
• InChI key: CWXPZXBSDSIRCS-UHFFFAOYSA-N

Description

Application

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves