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TTF-1 protein expression in pleural malignant mesotheliomas and adenocarcinomas of the lung.

Cancer letters (1998-03-21)
C Di Loreto, F Puglisi, V Di Lauro, G Damante, C A Beltrami
RESUMEN

TTF-1 is a tissue-specific transcription factor expressed in the epithelial cells of thyroid and lung. This study investigates the immunohistochemical expression of TTF-1 in pleural malignant mesotheliomas (MM) and adenocarcinomas (AC) of the lung, respectively. For this purpose, 33 biopsy specimens of pulmonary AC and 24 specimens of MM were studied. TTF-1 immunoreactivity was identified in 19 of 33 cases of AC (57.5%) and in none of the 24 cases of MM. Positivity for TTF-1 was 100% specific and 57.5% sensitive for lung AC. Alternatively, negativity for TTF-1 was 57.5% specific and 100% sensitive for MM. These results suggest that TTF-1 can be favourably added to the immunohistochemical diagnostic panel for distinction between AC of the lung involving the pleura and pleural MM.

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Sigma-Aldrich
TTF-1 (8G7G3/1) Mouse Monoclonal Antibody
Sigma-Aldrich
TTF-1 (EP229) Rabbit Monoclonal Primary Antibody