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Merck

Droperidol in the emergency department: is it safe?

The Journal of emergency medicine (2003-05-15)
John R Richards, Aaron B Schneir
RESUMEN

Droperidol is an antipsychotic and antiemetic drug that has been used extensively by emergency physicians, psychiatrists, and anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department.

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Sigma-Aldrich
Droperidol
USP
Droperidol, United States Pharmacopeia (USP) Reference Standard
Droperidol, European Pharmacopoeia (EP) Reference Standard