[The clinical efficacy and safety of intravenous cefmetazole in treatment of 1,522 patients with aspiration pneumonia].

To evaluate the efficacy and safety of intravenous cefmetazole in the treatment of patients with aspiration pneumonia. A multicenter, prospective and open-labeled trial was conducted. A total of 1522 patients were enrolled at the beginning, and only 1324 were evaluated at the endpoint. The duration of treatment was 7 - 14 days. During the treatment and follow-up periods, we recorded any unexpected symptoms and abnormal laboratory tests. At last, we evaluated its efficacy and safety. The total effective rate of cefmetazole was 79.8%(1056/1324). The total bacterial eradication rate was 75.0% (342/456). The bacterial eradication rates of Klebsiella pneumonia, Escherichia, Staphylococcus aureus and anaerobic bacteria were 78.2% (97/124), 80.8% (80/99), 89.0% (81/91), 9/11, respectively. Cefmetazole is effective and safe in the treatment of aspiration pneumonia.