Palladium-catalyzed reductive ortho-arylation: evidence for the decomposition of 1,2-dimethoxyethane and subsequent arylpalladium(II) reduction.

Palladium-catalyzed reductive ortho-arylation: evidence for the decomposition of 1,2-dimethoxyethane and subsequent arylpalladium(II) reduction.

Organic letters (2010-10-19)

Andrew Martins, David A Candito, Mark Lautens

PMID20949920

RESUMEN

A palladium-catalyzed crossed biaryl coupling/reduction sequence enables the formation of meta-substituted biaryls via solvent-mediated arylpalladium(II) reduction. Isotope labeling studies determined that the decomposition of 1,2-dimethoxyethane (DME) is indeed involved in the reductive process.

MATERIALES

Referencia del producto

Marca

Descripción del producto

E27408

Sigma-Aldrich

1,2-Dimethoxyethane, ReagentPlus^®, ≥99%, inhibitor-free

307432

Sigma-Aldrich

1,2-Dimethoxyethane, suitable for HPLC, 99.9%, inhibitor-free

259527

Sigma-Aldrich

1,2-Dimethoxyethane, anhydrous, 99.5%, inhibitor-free

72405

Supelco

1,2-Dimethoxyethane, analytical standard

09-1625

Sigma-Aldrich

1,2-Dimethoxyethane, SAJ first grade, ≥99.0%