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1046205

USP

Aztreonam

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

[2S-[2α,3β(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C13H17N5O8S2
CAS Number:
78110-38-0
Molecular Weight:
435.43
MDL number:
MFCD00072145
UNSPSC Code:
41116107
PubChem Substance ID:
329749093
NACRES:
NA.24
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grade

pharmaceutical primary standard

API family

aztreonam

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

C[C@H]1[C@H](NC(=O)\C(=N/OC(C)(C)C(O)=O)c2csc(N)n2)C(=O)N1S(O)(=O)=O

InChI

1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1

InChI key

WZPBZJONDBGPKJ-VEHQQRBSSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aztreonam USP reference standard is meant to use for specified quality tests and assays.

Also used to prepare standard and system suitability solutions for assay according to the given below monographs of United States Pharmacopeia (USP):
  • Aztreonam[1]
  • Aztreonam for Injection[2]
  • Aztreonam Injection[3]

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

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Aztreonam Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 462-462 (2018)
Aztreonam for Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 463-463 (2018)
Aztreonam
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(2), 460-460 (2020)
W C Hellinger et al.
Mayo Clinic proceedings, 74(4), 420-434 (1999-04-30)
Imipenem and meropenem, members of the carbapenem class of beta-lactam antibiotics, are among the most broadly active antibiotics available for systemic use in humans. They are active against streptococci, methicillin-sensitive staphylococci, Neisseria, Haemophilus, anaerobes, and the common aerobic gram-negative nosocomial
Kimberly A Pesaturo et al.
The Annals of pharmacotherapy, 46(7-8), 1076-1085 (2012-07-06)
To evaluate the pharmacology, clinical efficacy, and safety of aztreonam lysine for inhalation (AZLI) for cystic fibrosis (CF)-related signs and symptoms of pulmonary disease. Literature was searched in MEDLINE through PubMed and cross-referenced with EMBASE (1980-June 2012). The key search
View All Related Papers

Questions

  1. quelle est la solubilité de ce produit et ds quel solvant et eau ? Merci

    1 answer

    1. This is a product of the United States Pharmacopeia. Solubility testing has not been performed. However, the research product A6848 is tested for solubility at 50 mg/ml in a 1:1 mixture of dimethylformamide and methanol. Another research grade item, PZ0038, is tested for solubility at 2 mg/mL in DMSO. The solubility in water has not been determined.

      Please see the link below to review the datasheet for the research grade material, A6848:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/320/622/a6848pis.pdf

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