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M0689

Sigma-Aldrich

Myelin Basic Protein Antigen from human brain

≥95% (SDS-PAGE)

Synonym(s):

Myelin Antigen, Myelin Basic Protein

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About This Item

MDL number:
MFCD03457654
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

human brain

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

technique(s)

ELISA: suitable

UniProt accession no.

P02686

storage temp.

−20°C

Gene Information

human ... MBP(4155)

General description

Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).[1][2]

Application

Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.[3]

Biochem/physiol Actions

Determined using polyclonal and monoclonal antibodies against MBP.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS).[1] MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.[2]

Physical form

Lyophilized from 10mM HCl.

Other Notes

Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM3665
SLCJ9340
SLCG7602
SLCF4687
SLCF4297

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Distinct T cell signatures define subsets of patients with multiple sclerosis.
Johnson MC
Neurology? neuroimmunology & neuroinflammation, 3(5), e278-e278 (2016)
Localization of the human myelin basic protein gene (MBP) to region 18q22----qter by in situ hybridization.
Saxe DF
Cytogenetics and Cell Genetics, 39(4), 246-249 (1985)
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA
The Biochemical Journal, 472(1), 17-32 (2015)

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