Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 47(12), 2951-2962 (2009-08-12)
In this paper, we present a cumulative risk assessment of three anti-androgenic pesticides (vinclozolin, procymidone and prochloraz) using the relative potency factor (RPF) approach and an integrated probabilistic risk assessment (IPRA) model. RPFs for each substance were estimated for three
International journal of andrology, 31(2), 241-248 (2008-03-05)
The incidence of hypospadias is increasing in young boys, but it remains unclear whether human exposure to endocrine disrupting chemicals plays a role. Risk assessment is based on estimation of no-observed-adverse-effect levels for single compounds, although humans are exposed to
Toxicology and applied pharmacology, 237(2), 178-187 (2009-03-24)
To verify whether anti-androgens cause transgenerational effects on spermatogenesis and DNA methylation in rats, gravid Crl:CD(SD) female rats (4 or 5/group, gestational day (GD) 0=day sperm detected) were intraperitoneally treated with anti-androgenic compounds, such as vinclozolin (100 mg/kg/day), procymidone (100
Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act (FQPA) required the Environmental Protection Agency (EPA) to consider cumulative risk of chemicals that act via a common mechanism of toxicity. To this end
Journal of hazardous materials, 189(1-2), 222-228 (2011-03-09)
An evaluation of the Potential Dermal Exposure of workers to endosulfan and procymidone at the mix/load and application stages was done in small floricultural production units in Argentina. Seven experiments were performed with different operators under typical greenhouse conditions, based
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