A8199

N-Acetyl-L-cysteine

≥99% (TLC), suitable for cell culture, BioXtra

• Synonym(s): LNAC, NAC
• Linear Formula: HSCH₂CH(NHCOCH₃)CO₂H
• CAS Number: 616-91-1
• Molecular Weight: 163.19
• Beilstein: 1724426
• EC Number: 210-498-3
• MDL number: MFCD00004880
• UNSPSC Code: 12352209
• PubChem Substance ID: 24891213
• NACRES: NA.26

Properties

• product name: N-Acetyl-L-cysteine, BioXtra, ≥99% (TLC)
• product line: BioXtra
• Quality Level: 300
• Assay: ≥99% (TLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• impurities: ≤0.002% Phosphorus (P); ≤0.1% Insoluble matter
• ign. residue: ≤0.5%
• color: white to off-white
• mp: 106-108 °C (lit.)
• solubility: H₂O: 0.1 M at 20 °C, clear, colorless
• cation traces: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.1%; Pb: ≤0.001%; Zn: ≤0.0005%
• application(s): cell analysis
• storage temp.: 2-8°C
• SMILES string: CC(=O)N[C@@H](CS)C(O)=O
• InChI: 1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
• InChI key: PWKSKIMOESPYIA-BYPYZUCNSA-N

Description

Application

N-Acetyl-L-cysteine has been used to study its protective effect against styrene-induced cochlear injuries in rats. It has also been used as a supplement in basal chemically-defined medium (BDM) for the culture of oligodendrocyte precursor cells.

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves