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E-022

Supelco

EDDP perchlorate solution

1.0 mg/mL in methanol (as pyrolinium), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Methadone metabolite

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About This Item

Empirical Formula (Hill Notation):
C20H24ClNO4
CAS Number:
31161-17-8
Molecular Weight:
377.86
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as pyrolinium)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

C[N+]1=C(CC)C(C2=CC=CC=C2)(C3=CC=CC=C3)CC1C.O=Cl(=O)([O-])=O

InChI

1S/C20H24N.ClHO4/c1-4-19-20(15-16(2)21(19)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;2-1(3,4)5/h5-14,16H,4,15H2,1-3H3;(H,2,3,4,5)/q+1;/p-1

InChI key

FICCBMGBBWWZRF-UHFFFAOYSA-M

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General description

A certified Snap-N-Spike® solution of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

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Description
Pricing

M-007

(±)-Methadone solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

E-006

EDDP perchlorate, ampule of 10 mg, certified reference material, Cerilliant®

E-021

EDDP-D3 perchlorate solution, 100 μg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant®

E-057

EMDP hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-062

EDDP-D3 perchlorate solution, 1.0 mg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant®

M-008

(±)-Methadone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-019

(±)-Methadone solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-021

(±)-Methadone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-088

(±)-Methadone-D9 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-089

(±)-Methadone-D9 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mei-Han Huang et al.
Toxicology, 280(1-2), 1-9 (2010-11-26)
Methadone (Mtd) is a widely used opioid drug associated with the side effect of hyperprolactinemia. The mechanism of how Mtd induces prolactin secretion remains unclear. The effects of Mtd and its two main metabolites (EDDP: (±)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium percholarate and EMDP: 2-ethyl-5-methyl-3,3-dipnehyl-1-pyrroline)
Mathew George et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 432-435 (2012-08-18)
Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate
Ricarda Jantos et al.
Forensic science international, 226(1-3), 254-260 (2013-02-21)
Body fluids and tissues in 16 methadone (MTD)-associated fatalities were investigated to find out whether analysis of MTD and its metabolite 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) following enantioselective separation of both compounds may assist in the interpretation of MTD findings. Individual case histories
Cristiana Gambelunghe et al.
Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment
Maksymilian Kulza et al.
Przeglad lekarski, 67(10), 925-928 (2010-01-01)
Methadone maintenance therapy is one of the most popular treatments for opiate addiction. The easiest and the most reliable way to monitor the accuracy of the therapy is determination of methadone and its metabolites in biological material. The aim of
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