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B-034

Supelco

Bupropion hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C13H19Cl2NO
CAS Number:
31677-93-7
Molecular Weight:
276.20
EC Number:
200-659-6
MDL number:
MFCD00055209
UNSPSC Code:
41116107
PubChem Substance ID:
329773108
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

InChI

1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

InChI key

HEYVINCGKDONRU-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A3(6531)

Related Categories

General description

A certified solution standard suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing and pharmaceutical research. Bupropion is an antidepressant and smoking cessation drug sold under the trade names Wellbutrin® and Zyban®.

Application


  • Investigation of neurotoxic effects: Research on propofol′s potential neurotoxic impact on the hippocampus has deepened understanding of its effects on mitochondrial function. (Ebrahimi et al., 2024).

  • Enhancement of cardiopulmonary bypass outcomes: Propofol is used in clinical trials to explore its efficacy in reducing biomarkers of organ injury during cardiac surgery. (Smartt et al., 2024).

  • Development of nanoencapsulation techniques: Propofol is being researched for its encapsulation in nanocarriers to improve its delivery efficiency and reduce side effects. Such innovations in drug delivery are aimed at enhancing the pharmacological profile of anesthetics, making them safer and more effective (Abdoullateef et al., 2024).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Wellbutrin is a registered trademark of GlaxoSmithKline LLC
Zyban is a registered trademark of Everris International B.V.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Leonie S Brose et al.
Mayo Clinic proceedings, 88(3), 226-233 (2013-03-16)
To compare the effectiveness of varenicline and combination nicotine replacement therapy (NRT) for treating smokers attempting to stop, as it is unclear which of the 2 is more effective. Data from 167,487 treatment episodes in patients from 42 National Health
Ian A Cook et al.
The Journal of clinical psychiatry, 74(1), 51-56 (2013-02-20)
Clinical trials in major depressive disorder (MDD) commonly assess remission at a single endpoint. Complementary, clinically relevant metrics include the likelihood and speed of achieving sustained remission. A neurophysiologic measure, the Antidepressant Treatment Response (ATR) index, previously predicted 8-week outcomes
Frank T Leone et al.
Chest, 143(5 Suppl), e61S-e77S (2013-05-10)
Continued tobacco use in the setting of lung cancer management is frequently confounding and always of critical importance. We summarized the published literature concerning the management of tobacco dependence in patients with lung cancer and offer recommendations for integrating dependence
Georgia Tsiapa et al.
In vivo (Athens, Greece), 27(2), 171-176 (2013-02-21)
Smoking is related to a great variety of pathological conditions, many of which affect the respiratory system, such as lung cancer and chronic obstructive pulmonary disease (COPD). Smoking cessation should be an integral part of the therapeutic approach to patients
Danielle Baribeau et al.
Journal of addiction medicine, 7(3), 216-217 (2013-03-23)
Bupropion is an antidepressant commonly prescribed as a smoking cessation aid. It has effects on dopamine and norepinephrine, and can lower seizure threshold, particularly in overdose. Several cases of recreational use of bupropion via nasal insufflation have been reported in
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