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113727

Sigma-Aldrich

Norphenylephrine hydrochloride

98%

Synonym(s):

α-Aminomethyl-3-hydroxybenzyl alcohol hydrochloride, 3,α-Dihydroxyphenethylamine hydrochloride, Norfenefrine hydrochloride

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About This Item

Linear Formula:
HOC6H4CH(CH2NH2)OH · HCl
CAS Number:
4779-94-6
Molecular Weight:
189.64
EC Number:
225-323-6
MDL number:
MFCD00012879
UNSPSC Code:
12352100
PubChem Substance ID:
24847145
NACRES:
NA.22

Assay

98%

form

solid

mp

162-164 °C (lit.)

SMILES string

Cl.NCC(O)c1cccc(O)c1

InChI

1S/C8H11NO2.ClH/c9-5-8(11)6-2-1-3-7(10)4-6;/h1-4,8,10-11H,5,9H2;1H

InChI key

OWMFSWZUAWKDRR-UHFFFAOYSA-N

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Application

Norphenylephrine hydrochloride was used in the study of the effects of phenylephrine on the isolated heart of rabbit.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J C David et al.
Journal of neurochemistry, 53(1), 149-154 (1989-07-01)
Functions of octopamine in the mammalian brain are still not well known. An important aspect of this problem is the relationship between octopamines and catecholamines. Previous data have shown that their respective ontogenic evolutions are not parallel. Do the changes
M Maeda et al.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 41(5), 463-469 (1990-01-01)
[11C]-p- and m-octopamine hydrochloride were synthesized from [11C]HCN in a two-step sequence. Chemical and enzymatic approaches were used for the formation of the [11C]cyanohydrin intermediates as the key step. Isolated radiochemical yields of 0.7-2.3% at the end-of-synthesis were obtained with
O Oldenburg et al.
Deutsche medizinische Wochenschrift (1946), 124(1-2), 8-12 (1999-02-10)
A 71-year-old man was admitted because of treatment-resistant orthostatic hypotension of unknown aetiology. When aged 64 years he developed some impotence and later urinary incontinence and urinary frequency. At 68 years he noted vertigo on physical activity, and a year
R B Raffa et al.
European journal of pharmacology, 169(2-3), 317-320 (1989-10-10)
Administration of p-octopamine by intracerebroventricular (i.c.v.) or intrathecal (i.t.) routes, but not orally, produced antinociception in the acetylcholine-induced abdominal constriction test (ED50 = 24.8 and 3.6 micrograms, respectively). Likewise, i.c.v. and i.t., but not peripheral (up to 200 mg/kg s.c.)
J F Coulon et al.
Journal of neurochemistry, 52(5), 1418-1424 (1989-05-01)
Phenolamines, particularly octopamines, are of special importance in avoidance behavior. In the Roman low avoidance (RLA) strain, p-octopamine can induce locomotor behavioral activity that is normally observed in the Roman high avoidance (RHA) strain. For these reasons, the levels of
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