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Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

Nature neuroscience (2018-02-07)
Liang Han, Nathachit Limjunyawong, Fei Ru, Zhe Li, Olivia J Hall, Haley Steele, Yuyan Zhu, Julie Wilson, Wayne Mitzner, Marian Kollarik, Bradley J Undem, Brendan J Canning, Xinzhong Dong
RÉSUMÉ

Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

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Anticorps anti-substance P (douleur), clone NC1, culture supernatant, clone NC1, Chemicon®