1257007

Ethambutol hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : Ethambutol dihydrochloride, 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride, Emb
• Formule empirique (notation de Hill): C₁₀H₂₄N₂O₂ · 2HCl
• Numéro CAS: 1070-11-7
• Poids moléculaire : 277.23
• Numéro MDL: MFCD21364080
• Code UNSPSC : 41116107
• ID de substance PubChem : 329749762
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: ethambutol
• Fabricant/nom de marque: USP
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
• InChI: 1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
• Clé InChI: AUAHHJJRFHRVPV-BZDVOYDHSA-N

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.

Actions biochimiques/physiologiques

Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable