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X4879

Sigma-Aldrich

Xaliproden

≥97% (HPLC), solid

Synonyme(s) :

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Formule empirique (notation de Hill):
C24H22F3N · HCl
Numéro CAS:
90494-79-4
Poids moléculaire :
417.89
Numéro MDL:
MFCD00896209
Code UNSPSC :
12352200
ID de substance PubChem :
329830807
Nomenclature NACRES :
NA.77

Pureté

≥97% (HPLC)

Forme

solid

Couleur

white to off-white

Solubilité

DMSO: ≥5 mg/mL

Auteur

Sanofi Aventis

Température de stockage

2-8°C

Chaîne SMILES 

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

Clé InChI

WVHBEIJGAINUBW-UHFFFAOYSA-N

Informations sur le gène

human ... HTR1A(3350)

Actions biochimiques/physiologiques

5-HT1A serotonin receptor agonist; neuroprotectant

Caractéristiques et avantages

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Vincent Meininger et al.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 5(2), 107-117 (2004-06-19)
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal motor neuron disease. We carried out two randomized, double-blind, placebo-controlled, multi-centre, multi-national studies with xaliproden (a drug with neurotrophic effect) to assess drug efficacy and safety at two doses. Patients
Y Iwasaki et al.
Journal of the neurological sciences, 160 Suppl 1, S92-S96 (1998-12-16)
SR57746A(1-[2-(naphth-2-yl)ethy]]-4-(3-trifluoromethyl phenyl)-1,2,5,6-tetrahydropyridine, hydrochloride) is a non-peptide compound which has been shown to exhibit a wide range of neurotrophic effects both in vitro and in vivo. Here we examine the ability of SR57746A on axotomized spinal motor neuron death in the
J-C Martel et al.
British journal of pharmacology, 158(1), 232-242 (2009-06-11)
Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats. Xaliproden was tested on
Paul H Gordon et al.
Archives of neurology, 66(6), 758-761 (2009-06-10)
To examine how respiratory interventions affect survival as an outcome measure and to define survival rate for trials in amyotrophic lateral sclerosis. We reviewed the data of 3 phase 3 clinical trials and examined differences in times to death, tracheostomy
What we have learned from the Xaliproden Sanofi-aventis trials.
P Douillet et al.
The journal of nutrition, health & aging, 13(4), 365-366 (2009-03-21)
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