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U6508

Sigma-Aldrich

UCN-01

≥97% (HPLC), powder

Synonyme(s) :

KW-2401

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About This Item

Formule empirique (notation de Hill):
C28H26N4O4
Numéro CAS:
Poids moléculaire :
482.53
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77

Niveau de qualité

Pureté

≥97% (HPLC)

Forme

powder

Activité optique

[α]20/D 130 to 160°, c = 0.2 in DMSO

Conditions de stockage

protect from light

Couleur

light yellow

Solubilité

DMSO: >5 mg/mL
H2O: insoluble

Température de stockage

2-8°C

Chaîne SMILES 

[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8

InChI

1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1

Clé InChI

PBCZSGKMGDDXIJ-HQCWYSJUSA-N

Application

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Actions biochimiques/physiologiques

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Caractéristiques et avantages

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Les clients ont également consulté

S Akinaga et al.
Anti-cancer drug design, 15(1), 43-52 (2000-07-11)
UCN-01 (7-hydroxystaurosporine) is a protein kinase inhibitor which is under development as an anti-cancer agent in the USA and Japan. Although UCN-01 was originally isolated from the culture broth of Streptomyces sp. as a protein kinase C-selective inhibitor, its ultimate
Adrian M Senderowicz
The oncologist, 7 Suppl 3, 12-19 (2002-08-08)
Many tumor types are associated with genetic changes in the retinoblastoma pathway, leading to hyperactivation of cyclin-dependent kinases and incorrect progression through the cell cycle. Small-molecule cyclin-dependent kinase inhibitors are being developed as therapeutic agents. Of these, flavopiridol and UCN-01
Sung-Bau Lee et al.
Science advances, 4(8), eaat4985-eaat4985 (2018-08-14)
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1
Wuli Zhao et al.
Journal of experimental & clinical cancer research : CR, 37(1), 98-98 (2018-05-08)
A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, A35 might overcome the resistance of single-target top inhibitors and has no cardiac toxicity for not targeting top2β. In this
Bo Gao et al.
Carcinogenesis, 41(8), 1123-1133 (2019-11-20)
Isochorismatase domain-containing 1 (ISOC1) is a coding gene that contains an isochorismatase domain. The precise functions of ISOC1 in humans have not been clarified; however, studies have speculated that it may be involved in unknown metabolic pathways. Currently, it is

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