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U4010

Sigma-Aldrich

Urokinase from human kidney cells

lyophilized powder

Synonyme(s) :

u-Plasminogen activator

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About This Item

Numéro CAS:
9039-53-6
Numéro de classification (Commission des enzymes):
3.4.21.73 (BRENDA, IUBMB)
Numéro CE :
232-917-9
Numéro MDL:
MFCD00132566
Code UNSPSC :
12352204
eCl@ss :
32160410
Nomenclature NACRES :
NA.54

Forme

lyophilized powder

Poids mol.

heavy chain 30,400 Da
light chain 2000 Da

Température de stockage

2-8°C

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Application

Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture. It has also been used in plasminogen activation assay.

Actions biochimiques/physiologiques

Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
Urokinase was shown to augment proliferation of renal tumor cells.

Propriétés physiques

Supplied as a lyophilized powder containing human albumin, mannitol and NaCl.
The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons.

Autres remarques

Note: Higher activities are obtained when human plasminogen is used as substrate.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H334

Conseils de prudence

P261 - P284 - P501

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Urokinase Substrate III, Fluorogenic Suitable for the quantitative direct fluorescent assay of urokinase.

Sigma-Aldrich

672159

Urokinase Substrate III, Fluorogenic

Tissue plasminogen activator human

Sigma-Aldrich

T0831

Tissue plasminogen activator human

Benjamin J Buckley et al.
International journal of molecular sciences, 22(6) (2021-04-04)
The K+-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of matrix degradation and tumor cell
Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin beta and fabricated fibrin matrices
Gavin KM, et al.
Adipocyte, 6(3), 234-249 (2017)
J C Kirchheimer et al.
Carcinogenesis, 9(11), 2121-2123 (1988-11-01)
Primary cultures of renal cell carcinomas and of the corresponding normal adjacent kidney tissue from 6 patients were analyzed for the effects of exogenously added urokinase-type plasminogen activator on cell proliferation as compared to the effects of tissue type plasminogen
The multifaceted roles of Leptospira enolase
Salazar N, et al.
Research in Microbiology, 168(2), 157-164 (2017)
H R Lijnen et al.
The Journal of biological chemistry, 265(9), 5232-5236 (1990-03-25)
The mechanism of the activation of plasminogen by single-chain urokinase-type plasminogen activator (single-chain u-PA, scu-PA) was studied using rscu-PA-Glu158, a recombinant plasmin-resistant mutant of human scu-PA obtained by site-specific mutagenesis of Lys158 to Glu, and rPlg-Ala740, a recombinant human plasminogen
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