T2943
Tissue plasminogen activator chromogenic substrate
≥95% (HPLC), solid
Synonyme(s) :
TPA Activity Assay
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About This Item
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Produits recommandés
Niveau de qualité
Essai
≥95% (HPLC)
Forme
solid
Poids mol.
apparent mol wt 658.9
Solubilité
methanol: water (1:9): 25 mg/mL
Température de stockage
2-8°C
Description générale
Tissue plasminogen activator chromogenic substrate is a highly sensitive chromogenic peptide substrate for tissue plasminogen activator (tPA). It shows different sensitivity to native single-chain tPA (sc-tPA) and its fully active two-chain form (tc-tPA).
Application
Tissue plasminogen activator chromogenic substrate has been used:
- in tissue plasminogen activator inhibition assay[1]
- to determine the plasminogen activator (PA) activity by studying the glycosylation properties of tissue plasminogen activator (tPA) activities in effusions using concanavalin A-Sepharose (conA-S) chromatography[2]
- in inhibition assays and complex formation analyses of wild type (WT) neuroserpin (NS) and its variants[3]
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Mahdieh Bayat et al.
International journal of biological macromolecules, 130, 863-877 (2019-03-09)
Organic osmolytes, as major cellular compounds, cause protein stabilization in the native form. In the present study, the possible chaperone effects of the three naturally occurring osmolytes on the two-chain form of tenecteplase (tc-TNK), a recombinant, genetically engineered mutant tissue
Jesse Cahill et al.
Frontiers in molecular biosciences, 7, 574477-574477 (2020-10-08)
Although chemically inert, Xe and other noble gases have been shown to have functional effects on biological systems. For example, Xe is a powerful anesthetic with neuroprotective properties. Recent reports have claimed that Xe inhibits the activity of tissue plasminogen
Mark W C Hatton et al.
The Journal of laboratory and clinical medicine, 147(1), 27-35 (2006-01-31)
The VX2 tumor is derived from a papilloma virus-induced rabbit epithelial cell line. If VX2 tumor cells (trapped in a plasma clot) are introduced intravenously into NZW rabbits, the cells lodge in the lung capillary bed and produce tumors. Independently
Shadabi Bano et al.
IUBMB life, 72(10), 2180-2193 (2020-08-23)
Heparin cofactor II (HCII) is predominantly expressed in the liver and inhibits thrombin in blood plasma to influence the blood coagulation cascade. Its deficiency is associated with arterial thrombosis. Its cleavage by neutrophil elastase produces fragment that helps in neutrophil
Mohammad Farhan Ali et al.
Biochimica et biophysica acta. Proteins and proteomics, 1868(4), 140363-140363 (2020-01-20)
Neuroserpin (NS) is predominantly expressed in brain and inhibits tissue-type plasminogen activator (tPA) with implications in brain development and memory. Nature of conformational change in pathological variants in strand 6B and helix B of NS that cause a relatively mild
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