T2011

Trypsin inhibitor

powder

• Synonyme(s) : Ovomucoid
• Numéro CAS: 9035-81-8
• UNSPSC Code: 12352202
• NACRES: NA.77
• EC Number: 232-906-9
• MDL number: MFCD00082102

Propriétés

• Nom du produit: Trypsin inhibitor from chicken egg white, Type III-O (free of ovoinhibitor)
• biological source: chicken egg white
• Quality Segment: 300
• type: Type III-O (free of ovoinhibitor)
• form: powder
• mol wt: 27 kDa
• solubility: water: soluble 10 g/L
• storage temp.: 2-8°C

Description

General description

Ovomucoid or trypsin inhibitor is an abundant protein in most avian egg whites. The hen′s egg protein is composed of about 186 amino acid residues, and is highly glycosylated. Three tandem domains are each homologous with pancreatic trypsin inhibitor. It is highly immunogenic, and probably accounts for most cases of egg allergy.

Application

Trypsin inhibitor from chicken egg white has been used:

• to terminate proteolysis reaction
• in OVO-1 solution to triturate the cell suspension for the dissociation of retina
• in phosphate buffered saline for dissociation of cortices

Biochem/physiol Actions

Ovomucoid possesses trypsin inhibitor activity. It has several conformational and linear epitopes that can be bound by immunoglobulin E (IgE). It is highly stable against heat and proteolysis.

Other Notes

One trypsin unit will produce a ΔA₂₅₃ of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C; reaction volume 3.2 mL, 1 cm light path.

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Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)