SRP0700

STAT5B Protein

recombinant

• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Produit recombinant: expressed in baculovirus infected Sf9 cells
• Pureté: 70-90% (SDS-PAGE)
• Forme: frozen liquid
• Poids mol.: ~115 kDa
• Concentration: 0.2 μg/μL
• Numéro d'accès: BC065227
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... STAT5B(6777)

Description

Application

Useful for Western blot.

Actions biochimiques/physiologiques

Recombinant full-length human STAT5B was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. STAT5B or signal transducer and activator of transcription 5B is a member of the STAT family of transcription factors. STATs are phosphorylated by the receptor associated kinases and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B is activated in response to a variety of cytokines ⁽¹⁾. The JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development ⁽²⁾. STAT5B is critical for maintenance of tolerance in vivo and it is proposed that STAT5B is probably activated by IL2R.

Reconstitution

Formulated in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Stockage et stabilité

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable