TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2), also known as PARP5B, tanykyrase-2, or TNKL (GenBank Accession No. NM_025235) amino acids 849-1166 (end) with N-terminal GST-tag, MW=62kDa, expressed in Sf9 cells via a Baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Forme physique
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 Mm KCl, 4 mM glutathione, 20% glycerol, and 3 mM DTT.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Cell and tissue research, 323(1), 137-145 (2005-09-10)
Tankyrase, which functions at telomeres and other cellular compartments, is thought to be a positive regulator of telomerase; its isoenzyme tankyrase 2 has been cloned as a putative cancer antigen. This pilot immunohistochemical study was designed to examine whether tumors
The Journal of biological chemistry, 276(38), 35891-35899 (2001-07-17)
Tankyrase (TANK1) is a human telomere-associated poly(ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere length when overexpressed. Here we report characterization of a second human tankyrase, tankyrase 2 (TANK2), which can also interact with TRF1 but
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