SRP0412
Sestrin 2 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥35% (SDS-PAGE)
Synonyme(s) :
HI95, SES2, SEST2
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About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in baculovirus infected Sf9 cells
Pureté
≥35% (SDS-PAGE)
Forme
aqueous solution
Poids mol.
55 kDa
Conditionnement
pkg of 50 μg
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... SESN2(83667)
Description générale
Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3.
Application
Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats.
Actions biochimiques/physiologiques
Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Xudan Shi et al.
Neurobiology of disease, 95, 111-121 (2016-07-19)
Hypoxic ischemic (HI) encephalopathy remains the leading cause of perinatal brain injury resulting in long term disabilities. Stabilization of blood brain barrier (BBB) after HI is an important target, therefore, in this study we aim to determine the role of
Li-Xue Wang et al.
Frontiers in immunology, 10, 2797-2797 (2019-12-24)
Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation. In recent
Raúl P Oliveira et al.
Free radical biology & medicine, 163, 255-267 (2020-12-29)
Liver regeneration is a remarkably complex phenomenon conserved across all vertebrates, enabling the restoration of lost liver mass in a matter of days. Unfortunately, extensive damage to the liver may compromise this process, often leading to the death of affected
Dongdong Wu et al.
Life sciences, 267, 118941-118941 (2020-12-29)
Acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with complex pathology and pathogenesis. Since there is no specific treatment for ALI, it is important to study the mechanism of how ALI develop. Sestrin2
Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)
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