SML2170

HX531

≥98% (HPLC)

• Synonyme(s) : 4-(5H-2,3-(2,5-dimethyl-2,5-hexano)-5-methyl- 8-nitrodibenzo[b,e][1,4]diazepin-11-yl)benzoic acid, 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid, HX 531, HX-531
• Formule empirique (notation de Hill) : C₂₉H₂₉N₃O₄
• Numéro CAS: 188844-34-0
• Poids moléculaire : 483.56
• Numéro MDL: MFCD19690920
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: yellow to orange
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C1=CC2=C(C(C)(CCC2(C)C)C)C=C13)C(C=C4)=C(N=C3C5=CC=C(C=C5)C(O)=O)C=C4[N+]([O-])=O
• InChI: 1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)
• Clé InChI: SXKPGYKPQPYJER-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Antagonist of the retinoid X receptor (RXR)

HX-531 is a potent antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM. HX531 has been used in many studies of the various effects of retinoids and RXR activity in diseases such as diabetes, Parkinson′s disease, often as a control for agonists such as Bexarotene. It was recently shown to promote white adipogenic differentiation and inhibit both basal and Bexarotene-induced brown adipogenic differentiation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable