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SML0508

Sigma-Aldrich

Pentostatin

≥95% (HPLC)

Synonyme(s) :

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

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About This Item

Formule empirique (notation de Hill):
C11H16N4O4
Numéro CAS:
53910-25-1
Poids moléculaire :
268.27
Code UNSPSC :
12352200
ID de substance PubChem :
329825517
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

100

Essai

≥95% (HPLC)

Forme

powder

Activité optique

[α]/D +70 to +80°, c = 1 in H2O

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

H2O: 10 mg/mL, clear

Conditions d'expédition

wet ice

Température de stockage

−20°C

Chaîne SMILES 

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

Clé InChI

FPVKHBSQESCIEP-JQCXWYLXSA-N

Informations sur le gène

human ... ADA(100)

Application

Pentostatin has been used in in vivo anti-tumor studies.[1] It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.[2]

Actions biochimiques/physiologiques

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).
Pentostatin/2′-deoxycoformycin[3] is used to treat patients with Waldenström′s macroglobulinemia.[4]

Caractéristiques et avantages

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Autres remarques

Air sensitve; hygroscopic.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000404027
0000404029
0000354256
0000354256
0000404029

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Sigma-Aldrich

A4036

Adenosine

Inosine ≥99% (HPLC)

Sigma-Aldrich

I4125

Inosine

Adenosine ≥99%

Sigma-Aldrich

A9251

Adenosine

Lucie Svobodníková et al.
Ecotoxicology and environmental safety, 182, 109369-109369 (2019-06-27)
Growth and developmental changes in plants induced by pharmaceuticals reflect changes in processes at the cellular and subcellular levels. Due to their growth and cellular characteristics, plant cell suspension cultures can be a suitable model for assessing toxicity. In this
Solid tumor therapy by selectively targeting stromal endothelial cells
Liu S, et al.
Proceedings of the National Academy of Sciences of the USA, 113(28), E4079-E4087 (2016)
Pentostatin, cyclophosphamide and rituximab is a safe and effective treatment in patients with Waldenstrom?s macroglobulinemia
Herth I, et al.
Leukemia Lymphoma, 56(1), 97-102 (2015)
Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin).
Spiers AS, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2(12), 1336-1342 (1984)
Da-Tong Ju et al.
Nutrients, 11(7) (2019-07-25)
Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viability
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