Measured by the ability of antithrombin III to inhibit the activity of thrombin in the presence of heparin.
Recombinant human antithrombin III (AT-III) is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 49 kDa (amino acids 33-464). This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher specific activity of the protein. The protein is produced with no artificial tags.
Application
This recombinant human AT-III product can be used to study the mode of action of the enzyme, as well as its potential inhibitors. It may also be used as a standard, e.g. in antithrombin activity assay, and/or in in vivo studies.
Actions biochimiques/physiologiques
Antithrombin III (AT-III), or Serpin C1 is a serine protease inhibitor glycoprotein, is a member of the Serpin superfamily. Antithrombin III inactivates several components in the coagulation system, IIa,IXa and mainly thrombin and factor Xa. The inhibitory activity of Antithrombin III is potentiated and increased by the polysaccharide heparin. In addition to its abolishment of coagulation, Antithrombin III was also found to suppress proinflammatory mediators, in part by its anticoagulation action. Congenital antithrombin deficiency results in loss of Antithrombin III activity, and leads to thrombosis. Thus, human Antithrombin III enzyme may be prescribed for the treatment and prevention of thromboembolism, as well as for the prevention of perioperative and peripartum thromboembolism.
Clause de non-responsabilité
Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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