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SAB4504615

Sigma-Aldrich

Anti-phospho-LATS1/2 (pThr1079/1041) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-WARTS, Anti-wts

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 126 kDa

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100

Numéro d'accès NCBI

O95835
Q9NRM7

Numéro d'accès UniProt

O95835

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pThr1079/pThr1041)

Informations sur le gène

human ... LATS1(9113) , LATS2(26524)

Catégories apparentées

Description générale

Large tumor suppressor kinase 1/ 2 (LATS1/2) is a mammalian homologue of the Drosophila tumor suppressor gene (lats)/warts. LATS1 and LATS2 are encoded by the gene mapped to human chromosomes 6q23-25.1 and 13q11–q12 respectively. hLATS2 is highly expressed in skeletal muscle and heart. LATS1 encodes a putative serine/threonine kinase.

Immunogène

The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041.

Immunogen Range: 1041-1090

Actions biochimiques/physiologiques

Large tumor suppressor kinase 1 (LATS1) and LATS2 are the key kinase constituents of the Hippo pathway. They play a vital role in the regulation of tumor progression and cell cycle, via various mechanisms and signaling pathways. LATS1 acts as a tumor suppressor in cervical cancer by regulating the expression of cyclin E, p27, matrix metalloproteinase 9 (MMP9) and yes-associated protein 1 (YAP). Overexpression of LATS2 leads to the development of acute myeloid leukemia (AML). Therefore, it is considered as a potential therapeutic target for AML treatment.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

LATS1 suppresses proliferation and invasion of cervical cancer
Molecular Medicine Reports, 15, 1654-1660 (2017)
The expression analysis of LATS2 gene in de novo AML patients.
Gholami M
Medical Oncology (Northwood, London, England), 31, 961-961 (2014)
Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
Yabuta N
Genomics, 63, 263-270 (2000)
Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma.
Hisaoka M
Laboratory Investigation; a Journal of Technical Methods and Pathology, 82, 1427-1435 (2002)
Shanmin Zhao et al.
Cell death & disease, 11(1), 70-70 (2020-01-29)
Previous studies have shown that tumor necrosis factor (TNF)-α is a mediator of hepatotoxicity in liver injury. Moreover, TNF-α has also been reported to have a protective effect in liver regeneration, yet the function of TNF-α during liver injury remains
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