SAB4504268

Anti-phospho-TAK1 (pThr¹⁸⁴) antibody produced in rabbit

affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 67 kDa
• Espèces réactives: human, rat, mouse
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:1000; western blot: 1:500-1:1000
• Numéro d'accès NCBI: O43318
• Numéro d'accès UniProt: O43318
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pThr184)
• Informations sur le gène: human ... MAP3K7(6885)

Description

Description générale

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is encoded by MAP3K7. TAK1 is a 606-residue protein, that contains a serine-threonine/tyrosine-protein kinase catalytic domain and a C-terminal coiled-coil domain. It is a member of the mitogen-activated protein kinase kinase kinase family (MAP3K). This gene is mapped to human chromosome 6q15.

Immunogène

The antiserum was produced against synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184.

Immunogen Range: 161-210

Actions biochimiques/physiologiques

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) participates in the mitogen-activated protein kinase (MAPK)-p38 signaling pathway. This gene also participates in the autophagy process in retinal pigment epithelial cells. Mutations in MAP3K7 result in cardiospondylocarpofacial syndrome.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable