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Key Documents

SAB4502960

Sigma-Aldrich

Anti-TGF β Receptor II antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

TβR-II, TGF-β receptor type II, TGF-β type II receptor, TGFR-2, Transforming growth factor-β receptor type II

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 64 kDa

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

Numéro d'accès NCBI

P37173

Numéro d'accès UniProt

P37173

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TGFBR2(7048)

Description générale

Anti-TGF β Receptor II Antibody detects endogenous levels of total TGF β Receptor II protein.
Transforming growth factor β receptor 2 (TGFBR2) is a serine/threonine protein kinase, that belongs to the TGF β receptor subfamily. It is located on human chromosome 3p24.

Immunogène

The antiserum was produced against synthesized peptide derived from human TGF beta Receptor II.

Immunogen Range: 91-140

Application

Anti-TGF β Receptor II antibody has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Actions biochimiques/physiologiques

Transforming growth factor β receptor 2 (TGFBR2) plays an important role in signal transduction resulting in mitogenic responses. Mutation in TGFBR2 result in Loeys-Dietz syndrome and Marfan syndrome.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Heterozygous TGFBR2 mutations in Marfan syndrome.
Mizuguchi T, et al.
Nature Genetics, 36(8), 855?860-855?860 (2004)
Arthrogryposis as neonatal presentation of Loeys-Dietz syndrome due to a novel TGFBR2 mutation.
Valenzuela I, et al.
European Journal of Human Genetics, 60(6), 303-307 (2017)
A new candidate substrate for cell-matrix adhesion study: the acellular human amniotic matrix.
Guo Q, et al.
BioMed Research International, 2012, 10-10 (2012)
TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells.
Fricke F, et al.
Cell communication and signaling : CCS, 15(1), 14-14 (2017)
Toshiyuki Ko et al.
Nature communications, 13(1), 3275-3275 (2022-06-08)
Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart failure, but it remains elusive whether there is a common pathway to induce both events. Through single-cell RNA-seq, spatial transcriptomics, and genetic perturbation, we elucidate that high-temperature requirement
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