SAB4300135

Anti-phospho-PAK1/PAK2/PAK3 (pThr⁴²³/pThr⁴⁰²/pThr⁴²¹) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-ADE2 antibody produced in rabbit, Anti-CDKN1A antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit
• Numéro MDL: MFCD02097133
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 61-67 kDa; 68-74 kDa
• Espèces réactives: mouse, human, rat
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• Isotype: IgG
• Séquence immunogène: (R-S-TP-M-V)
• Numéro d'accès NCBI: NP_001121638.1; NP_001122092.1; NP_002568.2
• Numéro d'accès UniProt: Q13177
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pThr423/pThr402/pThr421)
• Informations sur le gène: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

Description

Immunogène

Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3.

Caractéristiques et avantages

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Description de la cible

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable