SAB4300110

Anti-phospho-CDK2 (pThr¹⁶⁰) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-cyclin-dependent kinase 2 antibody produced in rabbit, Anti-p33(CDK2) antibody produced in rabbit
• Numéro MDL: MFCD00675227
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~34 kDa
• Espèces réactives: rat, human, mouse
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (T-Y-TP-H-E)
• Numéro d'accès NCBI: NP_001789.2
• Numéro d'accès UniProt: P24941
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pThr160)
• Informations sur le gène: human ... CDK2(1017)

Description

Description générale

Cyclin-dependent kinase 2 (CDK2), a nucleus-cytoplasm trafficking protein, belongs to the cyclin-dependent kinase (CDK) family. The CDK2 gene is located on human chromosome 12q13.2.

Immunogène

Peptide sequence around phosphorylation site of threonine 160 (T-Y-T(p)-H-E), according to the protein CDK2.

Actions biochimiques/physiologiques

Cyclin-dependent kinase 2 (CDK2) protein participates in the recombination and differentiation of the cell. It plays a major role in metabolism, apoptosis, senescence, and meiosis. CDK2 is involved in the development of embryos and the remodeling of chromatin. It also plays a key role in DNA damage and DNA damage response (DDR). CDK2 controls the progression of the cell cycle. Changes in the activity of CDK2 might have an impact on human carcinogenesis. Absence of CDK2 results in DNA damage and DDR activation.

Caractéristiques et avantages

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Description de la cible

Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable