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Key Documents

SAB4200593

Sigma-Aldrich

Anti-Occludin antibody from rabbit

affinity isolated antibody

Synonyme(s) :

BLCPMG, OCLN, PPP1R115

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Espèces réactives

human

Technique(s)

immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

Numéro d'accès UniProt

Q16625

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... OCLN(100506658)

Description générale

Occludin (OCLN) is an integral membrane protein, encoded by the gene mapped to human chromosome 5q13.2. OCLN is a ~65 kDa protein with four transmembrane domains including, a long COOH-terminal cytoplasmic domain, a short NH2-terminal cytoplasmic domain, two extracellular loops, and one intracellular turn. It is specifically localized at tight junctions (TJ).

Application

Anti-Occludin antibody from rabbit has been used in immunocytochemistry and western blotting.

Actions biochimiques/physiologiques

Occludin (OCLN), along with tight junction (TJ)-associated peripheral membrane proteins, plays a vital role in formation and regulation of TJ. The encoded protein facilitates the translocation of p85a to TJs to regulate actin organization after oxidative stress. OCLN is also implicated in cell migration. Mutation in the gene leads to the development of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG).

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin.
Mikio F, et al.
The Journal of Cell Biology, 141(7), 1539?1550-1539?1550 (1998)
Recessive Mutations in the Gene Encoding the Tight Junction Protein Occludin Cause Band-like Calcification with Simplified Gyration and Polymicrogyria.
Mary C O, et al.
American Journal of Human Genetics, 87(3), 354?364-354?364 (2010)
Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry.
Kohaar I, et al.
Journal of Virology, 84(14), 6987-6994 (2010)
The tight junction protein, occludin, regulates the directional migration of epithelial cells.
Du D, et al.
Developmental Cell, 18(1), 52-63 (2010)
Dongli Li et al.
Stem cell research & therapy, 12(1), 24-24 (2021-01-09)
Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exists currently. Retinal pigmented epithelium (RPE) cells are crucial in maintaining the
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